# google-deepmind/alphaprotein-novo

> A generative diffusion pipeline for de novo enzyme design via structural motif scaffolding: it co-generates protein structures and sequences conditioned on a catalytic motif and ligand, with optional LigandMPNN redesign, AlphaFold 3 folding, and evaluation.

- Magnitude: 4.4 out of 10 — Early signal
- Stars: 104 total · +1 star measured 2026-10-06, 14:09–15:56 UTC, ≈ 9 by evening
- Star trust: star growth looks organic
- Category: Science & research · Language: Python · License: Apache-2.0 · Created: 2026-10-05 · Last push: 2026-10-06
- GitHub: https://github.com/google-deepmind/alphaprotein-novo · Page: https://gitnova.dev/en/r/google-deepmind/alphaprotein-novo

## Useful for

- Generate enzyme structures and sequences conditioned on a catalytic motif
- Run the full pipeline: diffusion, LigandMPNN redesign, AlphaFold 3 folding, metrics
- Verify the installation using the reduced-step Kemp eliminase test manifest

## Why it’s here

- Star-counter measurements on 2026-10-06 (UTC), 14:09–15:56: 103 → 104 stars (+1). This is the change over that interval.
- Estimated end-of-day forecast: about +9 stars, using observed gains and the previous day.
- The repository is 1 day old and already has 104 stars. With less than two weeks of history, there's no usual pace to compare the spike against yet.
- Top new repositories this week: #135.
- About 15 forks a day — people are taking the code.

## Star trust

Star growth looks organic.

Star-trust labels are heuristics based on the repository’s behavior, not a check of every stargazer.

## Numbers

- Forks: 16
- Issues and pull requests: 0
- Watchers: 0
- Average over the last week: 39 per day
- Usual pace: too little history (under two weeks)
- Stars in the last hour (measured): 0

## Stars per day, last 3 days (oldest → newest, today is partial)

2026-10-04 … 2026-10-06: 0, 70, 1

## Spotted in now

- Top new repositories this week: #135

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Magnitude (0–10) measures how fast and how unusually interest in a repository is growing right now. It is not a quality score.
Days are UTC. “So far today” is a fact; “expected by the end of the day” is a forecast.
Summaries and use cases are written by an LLM (DeepSeek V4.1 Flash) from the README and may be inaccurate: verify specific claims (benchmarks, speed, hardware) in the repository itself.
Data as of 2026-10-06 16:15 UTC, updated every 30 minutes.